According to the outcome of the recent research posted in the Journal of Clinical Investigation, a liver transplantation patient may have fewer health issues because of the intake of certain antibiotic pills. The pre-therapy with the use of antibiotics is also essential, judging from the publication made of the research held by UCLA scientists.
During 2013-2015, scientists were giving mice (rodents) different antibiotics at least 10 days before having a liver transplantation. The outcome demonstrated that most rodents who were given different antibiotic meds had a much better liver state after transplantation procedure.
Pre-transplantation therapy with antibiotics may also assist people who are going through liver transplantation surgery. The intake of antibiotics before surgery helped with the moderate inhibition of certain bacterial viruses that caused inflammation and decreased to the minimum the risks of organ rejection.
Antibiotics are also effective in restoration of the blood flow to the weakened liver that didn’t receive oxygen for a very long time. Certain medications also assisted with reduced cell damage and removal. In such way, the 2-year-study helped to reveal which bacteria are the best to respond to the pre-transplantation antibiotic therapy.
The UCLA scientists were not the only ones who researched the impact of pre-procedure therapy with antibiotics. A few additional studies resulted in a quite similar way – the rodents who received antibiotics before getting heart or skin transplants also eventually become healthier due to the reduced number of bacterial viruses.
The most recent research demonstrated that the rodents’ livers after the impact of antibiotic pills were protected against the widespread inflammation and abdication of transplants. In a way, antibiotics modulated the microbiomes in a human body and stimulated the natural protection of cells. The results of this research are incredible.
After the research on mice, the UCLA scientists investigated 264 patients. All of them received a liver transplant. Only 156 patients received pre-surgery antibiotic therapy for the 10-day period or more. 108 patients who didn’t get any antibiotics before a transplantation surgery were sicker than those patients who were taking antibiotics. Also, according to the researchers, the new livers of the patients who received the pre-surgery antibiotic treatment functioned much better compared to the patients who didn’t take any drugs before transplantation.
How do different antibiotics affect the liver?
Antibiotics are medications with the active components inhibiting the growth of living cells. Different antibiotics are widely used in the treatment of pathologies caused by bacteria. Sometimes these antibacterial medications are prescribed for liver diseases. In particular, antibiotics can help in cases where pathologies of the hepatobiliary system are accompanied by various infectious complications. In common, the effect of antibiotics on the liver is negative. Most drugs have a devastating effect on the functionality of the gallbladder and liver. However, it is possible to level the bad influence of antibacterial drugs and benefit from the use of antibiotics if you have a liver issue. Only a professional healthcare provider may assign the dose of antibiotics for a person before a liver transplantation surgery. International pharmacy may offer a detailed free consultation and a lot of discounts for people who seek the best antibiotics before liver transplantation.
The first thing that you need to understand – most antibiotics are active only against certain bacteria. There are drugs with a wide spectrum of activities that are detrimental to many strains of bacteria. Every drug is unique because they do not affect the certain target receptor that is not located in human tissues but directly affects the cells of a bacterial body. There are more than 300 antibiotics.
The most common types of antibiotics:
- Penicillin-based drugs. Synthesized from the waste products of bacteria. Penicillin belongs to the extensive class of beta-lactam antibiotics. Medicines have bactericidal effects. They affect the penicillin-binding proteins of bacteria needed to synthesize the biopolymer that builds the bacterial cell walls. Penicillin is detrimental to the so-called gram-positive bacterial types, listeria, gram-negative bacteria, anaerobes, spirochetes.
- There are 4 generations of cephalosporin. The drugs of this category disrupt the formation of bacterial cell walls, making the pathogenic microorganisms die. They have a wide spectrum of action. These pills are specifically effectual against most gram-negative and gram-positive bacterial viruses.
- These antibiotics are based on the macrocyclic lactone rings. The antimicrobial effect of drugs is simple – they disrupt the process of protein synthesis in bacteria. The macrolides are effective against gram-positive cocci. Also, macrolides have mild anti-inflammatory and the moderate immunomodulatory effect that is why they are recommended for people who have problems with inflammation due to the injured or diseased liver.
- These relatively new antibiotic drugs are commonly used for the treatment of infectious diseases. According to the mechanism of action, they are much different from other antibiotics. Fluoroquinolones (https://www.merckmanuals.com/professional/infectious-diseases/bacteria-and-antibacterial-drugs/fluoroquinolones) have a pronounced bactericidal effect. Their active components inhibit the production of DNA gyrase and topoisomerase IV, making bacteria die naturally in a human body. The gram-negative bacterial viruses can be reduced or totally killed with these pills. Fluoroquinolones can also destroy gram-positive bacteria and enterococci.
- Tetracycline is one of the earliest antibiotics. Tetracycline-derived pills provide the pronounced bacteriostatic effect. These drugs disrupt protein synthesis in microbial cells, making bacteria die. Tetracycline drugs are specifically effective against gram-positive cocci, spirochetes, borrelia, protozoa, mycoplasmas. But today, many bacteria have developed resistance to tetracycline-based pills, so these antibiotics are mostly not recommended by doctors.
- These first-line pills have a strong bactericidal effect. Aminoglycosides cause the death of bacteria due to the disruption of protein synthesis in ribosomes. Antibacterial medications of this group are effective against gram-negative cocci, staphylococci and some other bacteria.
Yes, some antibiotics can cause damage to a healthy liver or for the treatment of certain viral forms of hepatitis. However, the recent research on mice and men proved that certain antibiotics (appointed by doctors) manage significantly help people who are going through the complicated process of liver transplantation.